ea0010oc9 | Thyroid and pituitary | SFE2005
Brand O
, Heward J
, Brix T
, Carr-Smith J
, Connell J
, Hegedus L
, Hunt P
, Robinson B
, Wass J
, Wiersinga W
, Franklyn J
, Weetman|S##Gough A
Genetic variants consistently associated with the development of GravesÂ’ disease (GD) have, to date, been general autoimmunity loci including those within the HLA region, the CTLA-4 gene and most recently the PTPN22 gene encoding lymphoid tyrosine phosphatase (LYP). The thyrotophin receptor gene (TSHR) has recently however, been identified as the first GravesÂ’ disease specific susceptibility locus. To further refine association with disease and exclude populat...